I hated of Mice and Men. I was actually happy at the end, just 'cause I was done with that awful book. Steinbeck's no fun at all :-\
I know I've teared up at books, but I can't remember for sure which and where. I'll just list some that I might have cried over, had I considered it as an option:
-The Salmon of Doubt. Douglas Adams is dead
-The last Harry Potter, but mostly because it was over.
-1984, because Winston was completely broken. It's difficult to imagine something worse than that being done to someone.
-The Giver, with basically every revelation - it's people, living without color, love, discovery, a real family, and on, and on, and on. Boy, that was rough.
-The Last Battle (Narnia). The bit near the end where the bear guy dies, and all he can say is, "I don't understand." Wahhhhh
. And of course, Aslan turning away all gajillion of the people that don't believe in him. Meh.
That's all off the top of my head, though I know there's more... as for movies, all I've got right now is Children of Men. Goddamn, that was a great movie but sad as hell. I highly recommend all the above books, by the way.